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5-Amino-1mq
5-Amino-1mq

5-Amino-1mq

5-Amino-1MQ is a novel small-molecule compound designed to target nicotinamide N-methyltransferase (NNMT), an enzyme crucial in metabolic regulation. By specifically inhibiting NNMT, this compound aims to rebalance key cellular energy pathways. This action helps to increase levels of NAD⁺ and S-adenosylmethionine (SAM) while reducing a byproduct called 1-methylnicotinamide. This metabolic adjustment is intended to support healthier mitochondrial function and improve the body's ability to burn fat. Preclinical studies have shown that 5-Amino-1MQ is highly cell-permeable and effectively targets NNMT, leading to significant anti-obesity effects in animal models without affecting food intake or causing noticeable side effects.

  • Weight Management: May promote significant weight loss (Animal Study).
  • Reduced Body Fat: May lead to a substantial decrease in fat mass and fat cell size (Animal Study).
  • Improved Body Composition: May help preserve lean muscle even during calorie restriction (Animal Study).
  • Enhanced Lipid Profile: May help lower circulating cholesterol and improve triglyceride levels (Animal Study).
  • Better Blood Sugar Control: May improve the body's sensitivity to insulin (Animal Study).
  • Reversal of Fatty Liver: May significantly reduce fat accumulation in the liver (Animal Study).
  • Muscle Performance: May enhance endurance and muscle regeneration (Animal Study).
  • Increased Cellular Energy: May elevate cellular NAD⁺ levels and overall metabolic rate (Animal Study).
  1. Kraus, D., et al. (2014). Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature, 508(7495), 258–262.
  2. Neelakantan, H., et al. (2017). Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochemical Pharmacology, 147, 141–152.
  3. Sampson, C.M., et al. (2021). Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice. Scientific Reports, 11(1), 5637.
  4. Dimet-Wiley, A.L., et al. (2024). Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice. Scientific Reports, 14, 15554.
  5. Liu, J.-R., et al. (2021). Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes. BioMed Research International, 2021, Article ID 9924314.

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