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5-Amino-1mq
5-Amino-1mq

5-Amino-1mq

5-Amino-1MQ is a novel small-molecule compound designed to target nicotinamide N-methyltransferase (NNMT), an enzyme crucial in metabolic regulation. By specifically inhibiting NNMT, this compound aims to rebalance key cellular energy pathways. This action helps to increase levels of NAD⁺ and S-adenosylmethionine (SAM) while reducing a byproduct called 1-methylnicotinamide. This metabolic adjustment is intended to support healthier mitochondrial function and improve the body's ability to burn fat. Preclinical studies have shown that 5-Amino-1MQ is highly cell-permeable and effectively targets NNMT, leading to significant anti-obesity effects in animal models without affecting food intake or causing noticeable side effects. For research use only. Not for human or veterinary consumption. Not intended for diagnostic or therapeutic applications . This product is not classified under U.S. DEA List I or List II chemical regulations. No DEA registration or reporting requirements apply.

  1. Kraus, D., et al. (2014). Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature, 508(7495), 258–262.
  2. Neelakantan, H., et al. (2017). Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochemical Pharmacology, 147, 141–152.
  3. Sampson, C.M., et al. (2021). Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice. Scientific Reports, 11(1), 5637.
  4. Dimet-Wiley, A.L., et al. (2024). Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice. Scientific Reports, 14, 15554.
  5. Liu, J.-R., et al. (2021). Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes. BioMed Research International, 2021, Article ID 9924314.
  • Weight Management: May promote significant weight loss (Animal Study).
  • Reduced Body Fat: May lead to a substantial decrease in fat mass and fat cell size (Animal Study).
  • Improved Body Composition: May help preserve lean muscle even during calorie restriction (Animal Study).
  • Enhanced Lipid Profile: May help lower circulating cholesterol and improve triglyceride levels (Animal Study).
  • Better Blood Sugar Control: May improve the body's sensitivity to insulin (Animal Study).
  • Reversal of Fatty Liver: May significantly reduce fat accumulation in the liver (Animal Study).
  • Muscle Performance: May enhance endurance and muscle regeneration (Animal Study).
  • Increased Cellular Energy: May elevate cellular NAD⁺ levels and overall metabolic rate (Animal Study).

$90.00

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