NAD+

NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme found in all living cells that plays a central role in energy production, DNA repair, and overall cell health. It acts as a critical partner for enzymes involved in metabolism, helping to generate ATP, the body's main energy currency. NAD+ is also essential for a group of enzymes called sirtuins, which regulate gene expression, protein stability, and immune responses. As we age, or with inflammation and DNA damage, NAD+ levels can decline, potentially impacting cellular function. Supplementing with NAD+ precursors, along with practices like exercise and fasting, can help restore NAD+ levels, promoting cellular resilience and metabolic balance.

  • Improved Energy: Higher NAD+ levels support better mitochondrial function, which can improve energy production and fat burning. (Lab Study)
  • DNA Repair: NAD+ is crucial for enzymes that help repair damaged DNA, supporting genetic stability. (Lab Study)
  • Cellular Resilience: Restoring NAD+ may help cells better handle stress and reduce signs of aging. (Lab Study)
  • Metabolic Health: NAD+ can improve how the body uses glucose and fats, potentially enhancing insulin sensitivity. (Lab Study)
  • Brain Protection: Maintaining NAD+ levels may help protect brain cells from injury and support nerve health. (Lab Study)
  • Reduced Inflammation: NAD+ can influence immune cells and reduce inflammatory responses in the body. (Lab Study)
  • Increased NAD+ Levels: Oral forms of NAD+ precursors have been shown to significantly raise NAD+ levels in human blood. (Human Study)
  • Good Safety Profile: Studies indicate that NAD+ precursors are generally well-tolerated in humans at recommended doses. (Human Study)
  1. Covarrubias, A.J., et al. (2021). NAD+ metabolism and its roles in cellular processes during aging. Nature Reviews Molecular Cell Biology, 22(2), 119–141. https://pmc.ncbi.nlm.nih.gov/articles/PMC7963035/
  2. Xie, N., et al. (2020). NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential. Signal Transduction and Targeted Therapy, 5, 227. https://www.nature.com/articles/s41392-020-00311-7
  3. Cantó, C., et al. (2015). NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus. Cell Metabolism, 22(1), 31–53. https://pmc.ncbi.nlm.nih.gov/articles/PMC4487780/
  4. Berven, H., et al. (2023). NR-SAFE: a randomized, double-blind safety trial of high-dose nicotinamide riboside (up to 3000 mg/day). Nature Partner Journals Aging, 9, 30. https://www.nature.com/articles/s41467-023-43514-6
  5. Henderson, J.D., et al. (2024). The use of a systems approach to increase NAD+ in humans: a randomized, placebo-controlled crossover trial. NPJ Systems Biology and Applications, 10, 13. https://www.nature.com/articles/s41514-023-00134-0

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