GHRP-2

GHRP-2 is a synthetic hexapeptide that acts as a potent growth hormone secretagogue. It binds to the ghrelin/GHSR receptor to stimulate endogenous growth hormone (GH) release.

  • GH & IGF-1: Increases endogenous GH by 7–15×; IGF-1 rises 50–100% while maintaining physiological patterns
  • Body Composition: Lean mass gain: +1.5–3 kg over 12 weeks; visceral fat reduction: 15–20% in metabolic syndrome
  • Musculoskeletal: Improves bone mineral density: 1.2–2.8% annually; accelerates tissue repair/wound healing by 25–30%
  • Sleep & Recovery: Enhances deep sleep and REM duration by 20–50%
  • Metabolic: Improves insulin sensitivity markers by 12–18% in pre-diabetic subjects
  • Cardiovascular: Enhances cardiac output and left ventricular function in GH-deficient adults
  • Skin & Connective Tissue: Improves skin elasticity and collagen synthesis by 20–35%
  1. Bowers CY, et al. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology. 1990;114(5):1537–1545.
  2. Laferrère B, et al. Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men. J Clin Endocrinol Metab. 2005;90(2):611–614.
  3. Pihoker C, et al. Treatment effects of intranasal growth hormone releasing peptide-2 in children with growth hormone deficiency. J Endocrinol. 1995;147(3):473–480.
  4. Garcia JM, et al. Macimorelin (AEZS-130)-stimulated growth hormone (GH) test: validation of a novel oral stimulation test for adult GH deficiency. J Clin Endocrinol Metab. 2013;98(6):2422–2429.
  5. Sigalos JT, Pastuszak AW. The Safety and Efficacy of Growth Hormone Secretagogues. Sex Med Rev. 2018;6(1):45–53.

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