Home All Products GHRP-2
GHRP-2
GHRP-2

GHRP-2

GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide that binds to the ghrelin/GHSR receptor. It is widely used in research models to study mechanisms related to growth hormone (GH) secretion, neuroendocrine signaling, and pituitary function.

Mechanism of Action (Research Context Only)

  • Pituitary Interaction
GHRP-2 binds to the growth hormone secretagogue receptor (GHSR-1a), a pathway involved in GH signaling in controlled laboratory systems.
  • Hypothalamic Amplification
Experimental models show that GHRP-2 can influence pathways that regulate pulsatile GH release, making it a commonly studied tool in endocrine research.


Because it acts through endogenous pathways, GHRP-2 is frequently used in studies examining physiological GH patterns rather than exogenous GH exposure.

  1. Bowers CY, et al. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology. 1990;114(5):1537–1545.
  2. Laferrère B, et al. Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men. J Clin Endocrinol Metab. 2005;90(2):611–614.
  3. Pihoker C, et al. Treatment effects of intranasal growth hormone releasing peptide-2 in children with growth hormone deficiency. J Endocrinol. 1995;147(3):473–480.
  4. Garcia JM, et al. Macimorelin (AEZS-130)-stimulated growth hormone (GH) test: validation of a novel oral stimulation test for adult GH deficiency. J Clin Endocrinol Metab. 2013;98(6):2422–2429.
  5. Sigalos JT, Pastuszak AW. The Safety and Efficacy of Growth Hormone Secretagogues. Sex Med Rev. 2018;6(1):45–53.

*Summaries reflect in-vitro, ex-vivo, and animal-model findings only. No human medical claims

  • Endocrine & Pituitary Studies: GHRP-2 is extensively used to investigate GH-axis responsiveness, receptor signaling, and interactions between ghrelin pathways and somatotroph activity.
  • Cellular & Tissue Research: Models have examined GHRP-2 in the context of protein synthesis pathways, mitochondrial signaling, and cellular metabolic activity.
  • Metabolic Pathway Investigations: Preclinical systems have explored GHRP-2’s impact on glucose-related signaling, lipid metabolism pathways, and insulin-related processes.
  • Sleep & Neurological Models: Animal and mechanistic studies have evaluated GHRP-2 in relation to circadian signaling, REM patterns, and neuroendocrine feedback loops.
  • Connective-Tissue Studies: In vitro studies have examined collagen expression markers and extracellular-matrix activity under GHRP-2 exposure.

$83.00

Per Unit
In stock

Free Shipping on All Orders $1000+