Gonadorelin itself (the drug ingredient) IS FDA-approved, but only in specific prescription drug formulations — for example:

• Factrel® (gonadorelin hydrochloride)
• Lutrepulse® (no longer sold in the U.S.)

Overview: Gonadorelin is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH). It binds to GnRH receptors (GnRHR) in pituitary gonadotroph cells and is used in research settings to study pulsatile vs continuous GnRH signaling, pituitary physiology, and hypothalamic-pituitary-gonadal (HPG) axis regulation.

• Pulsatile Exposure: Intermittent administration of GnRH stimulates pituitary gonadotropes, leading to cyclic release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This pattern is frequently modeled in laboratory studies examining reproductive endocrinology.
• Continuous Exposure: Sustained GnRH exposure can lead to receptor desensitization and downregulation of gonadotropin secretion. This is commonly used in research exploring pituitary suppression, receptor dynamics, and desensitization pathways.
• HPG Axis Modeling: Gonadorelin is widely used in academic research to investigate hormonal signaling, pituitary responsiveness, feedback mechanisms, and gonadal steroidogenesis under various experimental conditions.