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IGF-1LR3
IGF-1LR3

IGF-1LR3

IGF-1 LR3 is a synthetic analog of native IGF-1 designed for research applications. It features an arginine substitution at position 3 (Arg3) and an extended peptide sequence, modifications frequently used in laboratory settings to examine stability, receptor interaction, and anabolic signaling pathways.
Research Modifications

  • Increased stability and extended half-life in vitro
  • Enhanced IGF-1 receptor binding affinity
  • Altered anabolic signaling compared to native IGF-1


In preclinical and in vitro studies, IGF-1 LR3 is used to investigate:

  • Binding interactions with IGF-1 receptors on muscle, tendon, ligament, and bone cells
  • PI3K/Akt/mTOR signaling pathways associated with:
    • Protein synthesis
    • Cellular proliferation
    • Tissue-repair modeling
  • Glucose-uptake and insulin-sensitivity pathways in cellular models

Clinical References

  1. Frost RA, Lang CH. Regulation of insulin-like growth factor-1 expression and its role in the growth of skeletal muscle. Growth Horm IGF Res. 2007;17(5):331–322.
  2. Barton-Davis ER, et al. IGF-1 LR3 increases muscle mass and strength in mice. J Clin Invest.1998;103(2):289–300.
  3. Rob, PT et al. Insulin-like growth factor-1 (IGF-1) promotes vascular repair and improves endothelial function in aging. Mol Ther. 2009;17(11):1679–1685.
  4. Clemmons DR. Role of IGF-1 in the management of growth and metabolism. J Clin Endocrinol Metab. 2007;92(1):1419–1427.

*Summaries below reflect findings from animal studies, cell cultures, and preclinical literature only. Not indicative of human effects.

Cellular Growth & Signaling Models

  • Muscle-Growth Signaling: Studied for its effects on satellite-cell activity and anabolic pathways (Animal Study).
  • Protein-Synthesis Pathways: Frequently used in models exploring enhanced mTOR and Akt signaling (In Vitro Study).

Recovery & Structural Tissue Studies

  • Tissue-Repair Modeling: Investigated for roles in tendon, ligament, and skeletal-muscle cell-response pathways (Animal Study).

Metabolic Pathway Research

  • Glucose-Utilization Models: Used to examine glucose uptake and insulin-receptor signaling (In Vitro Study).

Skeletal-System Studies

  • Bone-Density Models: Studied for osteogenic signaling and structural-tissue support pathways (Animal Study).

Vascular Biology

  • Angiogenesis Signaling: Used in research exploring endothelial-cell behavior and vascular-growth factors (Animal Study).

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