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Ipamorelin
Ipamorelin

Ipamorelin

Overview: Ipamorelin is a synthetic pentapeptide and selective growth-hormone secretagogue (GHS) frequently used in laboratory settings to study GH-related signaling via the GHS-R1a receptor. Unlike broader GHRPs, Ipamorelin is examined for its ability to stimulate GH release with minimal activity at receptors influencing ACTH, cortisol, prolactin, FSH, LH, or TSH in preclinical models.

  • Half-Life: ~2 hours in preclinical studies
  • Time to Peak GH Release: ~0.67 hours in laboratory models
  • Mechanistic Pathways: Activation of cAMP/PKA signaling, supporting pulsatile GH-release patterns observed in experimental settings


Ipamorelin is frequently studied for dose-proportional GH secretion, high receptor selectivity, and reduced interaction with non-GH endocrine targets in preclinical laboratory systems.

Clinical References

  1. Goubbrug JY, et al. (1999). Pharmacokinetic-pharmacodynamic modeling of ipamorelin. Pharm Res, 16(9): 1421–1426.
  2. Beck DE, et al. (2014). Prospective, randomized, controlled study of ipamorelin for postoperative ileus management (research context only). J Gastrointest Surg, 19(7): 1232–1242.
  3. Raun K, et al. (1999). The first selective GH secretagogue. Eur J Endocrinol, 139(6): 552–561.
  4. Jadhav PB, et al. (1998). Pharmacokinetics of ipamorelin in preclinical models. Xenobiotica, 28(11):1083-1092.
  5. Ishida J, et al. (2020). Growth-hormone secretagogues: history, mechanisms, research significance. JCSM Rapid Commun, 3(1): 25–37.

*Descriptions summarize animal, in vitro, and preclinical findings only. Not indicative of human effects.

GH Pathway Research

  • Selective GH Signaling: Studied for GH-specific receptor interactions without elevation of other pituitary hormones (Preclinical Study).
  • Pulsatile GH Dynamics: Frequently used to model physiologic-like pulsatile GH release cycles in controlled experimental settings.
  • Injection-Interval Modeling: Longer half-life allows exploration of reduced dosing frequency compared to other GHRPs in research animals.

Tissue-Signaling & Recovery Pathways

  • GH-Linked Repair Models: Preclinical studies explore effects on fibroblast activity, collagen pathways, and healing-related signaling.
  • Myogenic & Metabolic Signaling: Used to examine GH/IGF-1-linked pathways including glucose uptake, lipid metabolism, and anabolic signaling (Animal Study).

Sleep & Neurological Models

  • Sleep-Architecture Research: Examined for effects on slow-wave sleep markers in animal models of GH release.

Safety-Profile Exploration

  • Selective Mechanism: Studied for minimized off-target hormonal effects compared to older GHRPs (Preclinical Research).

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