Kisspeptin

Kisspeptin is a family of neuropeptides that serve as the master regulator of reproductive hormones. They act directly on KISS1R receptors located on hypothalamic GnRH neurons, triggering the Gαq/11-PLC-β signaling cascade, which results in GnRH release. This, in turn, stimulates LH and FSH secretion from the anterior pituitary.

Fertility/IVF: 85% pregnancy rate in high-risk patients; 98.4% oocyte maturation success; eliminates severe OHSS risk
Reproductive Hormone Restoration: 3× increase in LH; 44.6% increase in testosterone in men; 15% increase in FSH with preserved specificity
Hypogonadism/Puberty: Restores GnRH pulsatility in hypothalamic amenorrhea or hypogonadism; 100% diagnostic accuracy in delayed puberty prediction
Sexual Function: Improves sexual brain processing and symptoms in hypoactive sexual desire disorder; penile tumescence improvements in men
Safety/Convenience: Reversible, minimal off-target hormonal effects; exceptional safety profile in clinical trials

Abbara, A., et al. (2020). Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders. J Clin Invest, 130(12), 6739-6753. DOI: 10.1172/JCI139681
Jayasena, C.N., et al. (2014). Kisspeptin-54 triggers egg maturation in women undergoing IVF. J Clin Invest, 124(8), 3667-3677. DOI: 10.1172/JCI75730
Mills, E.G., et al. (2023). Effects of kisspeptin on sexual brain processing in men with hypoactive sexual desire disorder. JAMA Netw Open, 6(2), e2254313. DOI: 10.1001/jamanetworkopen.2022.54313
Chan, Y.M., et al. (2020). Using kisspeptin to predict pubertal outcomes in youth with pubertal delay. J Clin Endocrinol Metab, 105(8), e2717-e2725. DOI: 10.1210/clinem/dgaa162
Hu, K.L., et al. (2022). Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction. Reprod Biol Endocrinol, 20(1), 81. DOI: 10.1186/s12958-022-00953-y

$83.00

Per Unit

In stock