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Kisspeptin
Kisspeptin

Kisspeptin

Kisspeptin is a family of neuropeptides widely used in laboratory environments to study regulation of the hypothalamic–pituitary–gonadal (HPG) axis. It binds to KISS1R (GPR54) receptors on hypothalamic GnRH neurons, initiating the Gαq/11–PLCβ signaling cascade, which triggers GnRH release. This pathway is frequently explored in preclinical research related to reproductive neuroendocrinology.

Forms Commonly Studied

  • Kisspeptin-54 (full-length peptide; longer half-life)
  • Kisspeptin-10 (shorter fragment; rapid onset)


Research interest includes pharmacokinetics, receptor activity, and downstream signaling effects in both in vitro and animal models.

Clinical References

  1. Abbara, A., et al. (2020). Kisspeptin receptor pathways and neuroendocrine regulation. J Clin Invest, 130(7), 3673–3675.
  2. Jayasena, C.N., et al. (2014). Kisspeptin signaling mechanisms in reproductive neuroendocrinology. J Clin Invest, 124(1), 367–377.
  3. Mills, E.G., et al. (2023). Kisspeptin signaling in hypothalamic circuits: mechanistic insights from preclinical research. JAMA Netw Open, 6(12).
  4. Chan, Y.M., et al. (2020). Kisspeptin-KISS1R axis in developmental and pubertal regulation. J Clin Endocrinol Metab, 105(1), e277–e285.
  5. Hu, K.L., et al. (2022). Advances in understanding the kisspeptin–GnRH pathway in reproductive biology. Reprod Biol Endocrinol, 20(1).

*All statements describe in vitro, mechanistic, or animal-model research only. Not indicative of human outcomes.

Neuroendocrine Regulation

  • GnRH Pathway Activation: Kisspeptin is a key upstream regulator of GnRH neurons and is widely used to study pulsatile GnRH release (Animal Study).

HPG Axis Modeling

  • LH/FSH Release: Kisspeptin stimulation of KISS1R is used to evaluate LH and FSH secretion patterns and downstream reproductive signaling (Lab Study).

Puberty-Onset Mechanisms

  • Developmental Timing Models: Kisspeptin is used to investigate the timing and regulation of pubertal development and neuroendocrine maturation (Animal/Translational Research).

Sex-Steroid Signaling Models

  • Reproductive Hormone Mapping: Research models use kisspeptin to examine feedback loops between GnRH, LH/FSH, and sex-steroid hormone production (Preclinical Study).

Neurobehavioral Interactions

  • Brain-Region Involvement: Preclinical studies assess kisspeptin’s effect on limbic and hypothalamic circuits involved in reproductive behavioral signaling (Animal Model).

Selectivity & Safety in Research Context

  • Targeted Mechanisms: Kisspeptin demonstrates high specificity for reproductive neuroendocrine pathways with minimal activity on unrelated endocrine receptors in controlled laboratory settings.

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