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MOTS-C
MOTS-C

MOTS-C

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a 16-amino acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA gene. It represents a novel mechanism of mitochondrial-nuclear communication, linking cellular energy status to gene expression.

  • Insulin Sensitivity: 30% increase in glucose infusion rate (Cell Metabolism, 2015)
  • Exercise Mimetic: Boosts MOTS-C post-exercise to improve metabolic adaptations (Nature Communications, 2021)
  • Cardiac Function: Enhanced systolic function and cardiac output (Cell Metabolism, 2018)
  • Physical Performance: Increases lifespan and maximal performance in preclinical models
  • Obesity Prevention: Improves energy expenditure and glucose utilization (PMC Review, 2022)
  • Bone Preservation: Prevents bone loss and enhances mineral density
  • Cognitive Benefits: Reduces pro-inflammatory cytokines, supports memory
  • Anti-inflammatory: Increases IL-10, reduces systemic inflammation
  • Autoimmune Diabetes Protection: Enhances regulatory T cell activity
  • Thermogenesis: Activates brown adipose tissue and upregulates thermogenic genes
  1. Cell Metabolism (2015) – Discovery and metabolic effects
  2. Cell Metabolism (2018) – Nuclear translocation mechanism
  3. Nature Communications (2021) – Exercise regulation & muscle homeostasis
  4. Journal of Translational Medicine (2023) – Mechanistic review
  5. PMC Review (2022) – Aging and age-related diseases

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