Home All Products KPV
KPV
KPV

KPV

NF-κB Pathway Modulation: In preclinical and cell-based studies, KPV has been shown to interact with importin-α3, which may help limit NF-κB nuclear translocation — a pathway involved in inflammatory signaling.

Targeted Cellular Uptake: Research indicates that KPV can enter epithelial cells and exert localized effects without broad systemic immunosuppression in experimental models.

Receptor-Independent Activity: Unlike α-MSH, KPV exhibits anti-inflammatory activity that appears independent of melanocortin receptor signaling, based on laboratory studies.

Clinical References

  1. Dalmasso, G., et al. (2008). “PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.” Gastroenterology, 134(1), 166–178.
  2. Kermanizadeh, K., et al. (2008). “Melanocortin-derived tripeptide KPV exhibits anti-inflammatory potential in IBD models.” Inflammatory Bowel Diseases, 14(3), 324–331.
  3. Land, S. C., et al. (2012). “Inhibition of inflammatory pathways by melanocortin-related peptides.” Cellular and Molecular Life Sciences, 69(13), 2261–2277.
  4. Xiao, B., et al. (2017). “Orally targeted delivery of KPV via nanoparticles enhances retention in models of colitis.” Molecular Therapy, 25(7), 1618–1640.
  5. Pawar, A. S., et al. (2017). “Transdermal iontophoretic delivery of KPV across skin models.” Journal of Pharmaceutical Sciences, 106(7), 1811–1816.

*All findings below are based on preclinical, in vitro, animal, or limited human data, and are not approved indications.

  • Anti-Inflammatory Support: Laboratory and epithelial-cell models show potential reductions (35–50%) in pro-inflammatory cytokines via NF-κB pathway modulation.
  • Intestinal Barrier Support: Animal and cell-based studies suggest KPV may help reduce myeloperoxidase activity and support epithelial lining integrity in experimental inflammation models.
  • Wound Healing & Tissue Support: Preclinical data suggest KPV may assist epithelial barrier restoration and may influence collagen organization and angiogenesis in wounded tissue models.
  • Antimicrobial Activity (Exploratory): Early laboratory research indicates potential activity against S. aureus and C. albicans.
(Not clinically validated as an antimicrobial treatment.)
  • Drug-Delivery Research: Studies investigating nanoparticle and iontophoretic delivery show enhanced transdermal penetration and targeted tissue distribution.
(Exploratory pharmaceutical-science research.)
  • Safety Profile (Research-Based): Non-clinical models suggest KPV may avoid corticosteroid-like immunosuppression and may remain active even in the presence of certain melanocortin receptor variants.
(Human safety data remain limited.)

$98.00

Per Unit
In stock

Free Shipping on All Orders $1000+