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Melanotan 1

Melanotan 1 (Afamelanotide) is a synthetic analog of α-melanocyte–stimulating hormone (α-MSH). It acts as a melanocortin-1 receptor (MC1R) agonist, stimulating eumelanin production in melanocytes.

Sunlight Tolerance: 70% increase in pain-free sun exposure in EPP patients
Photoprotection: 50% fewer phototoxic reactions vs placebo
Quality of Life: Greater outdoor activity participation and lifestyle improvement
Skin Pigmentation: Sustained eumelanin production, providing UV protection and reduced DNA damage
First Effective EPP Treatment: Clinically significant reduction in phototoxicity symptoms
Safety & Tolerability: Well-tolerated; mild adverse effects reported

Langendonk, J.G., et al. (2015). “Afamelanotide for Erythropoietic Protoporphyria.” New England Journal of Medicine, 373(1), 48–59. DOI link
Biolcati, G., et al. (2015). “Long‐term observational study of afamelanotide in 115 patients with EPP.” British Journal of Dermatology, 172(6), 1601–1612.
Wensink, D., et al. (2020). “Association of Afamelanotide With Improved Outcomes in EPP Patients.” JAMA Dermatology, 156(5), 570–575.
Kim, E.S., & Garnock-Jones, K.P. (2016). “Afamelanotide: A Review in EPP.” American Journal of Clinical Dermatology, 17(2), 179–185.
Minder, E.I., et al. (2017). “Pharmacokinetics and Pharmacodynamics of Afamelanotide.” Clinical Pharmacokinetics, 56(8), 815–823.

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