Home All Products MT-2 (Melanotan 2 Acetate)
MT-2 (Melanotan 2 Acetate)
MT-2 (Melanotan 2 Acetate)

MT-2 (Melanotan 2 Acetate)

Overview: Melanotan 2 (MT-2) is a cyclic analog of α-melanocyte–stimulating hormone (α-MSH). It is a non-selective melanocortin receptor agonist studied for its interactions with:

  • MC1R
  • MC3R
  • MC4R

These receptors participate in pigmentation biology, energy balance, and central melanocortin pathways.
Formulation: Lyophilized peptide powder for laboratory research
Regulatory Status: Not FDA-approved for any medical, diagnostic, or therapeutic use.

Mechanistic Notes (Research Context Only)Pigmentation PathwaysMT-2 activates MC1R in melanocytes, which is studied for its role in:

  • Eumelanin production
  • UV-independent pigmentation models

Central Melanocortin SignalingBecause MT-2 can cross the blood–brain barrier, studies show it interacts with MC4R, a receptor involved in:

  • Appetite regulation pathways
  • Energy balance signaling
  • Behavioral and neuroendocrine melanocortin networks

Peripheral EffectsResearch explores its influence on:

  • Insulin and glucose-related signaling pathways
  • Metabolic markers
  • Body composition models in preclinical systems
  • Structure–Function RelationshipMT-2 is a precursor molecule from which bremelanotide (PT-141) was derived, the only FDA-approved melanocortin analog for sexual-health indications.
    
MT-2 itself, however, remains research-only.

Clinical References

  1. Don, R.T., et al. (1996). Melanocortin receptor interactions of MT-2. Life Sciences, 58(20), 1777–1784.
  2. Wessells, H., et al. (1998). Melanocortin peptides and receptor activity. Journal of Urology, 160(2), 389–393.
  3. Wessells, H., et al. (2000). Experimental studies of melanocortin pathways. International Journal of Impotence Research, 12(S4), S74–S79.
  4. Strader, A.D., et al. (2007). MC receptor pharmacology and signaling. Journal of Pharmacology and Experimental Therapeutics, 322(3), 1153–1161.
  5. Uckert, S., et al. (2014). Investigational melanocortin agonists. Expert Opinion on Investigational Drugs, 23(11), 1477–1483.

*Descriptions summarize animal or laboratory studies; not indicative of human outcomes

  • Pigmentation Models: MC1R activation is used to study processes associated with melanin synthesis, photoprotection pathways, and skin-pigment regulation.
  • Energy-Balance Research: MC4R engagement is studied for effects on appetite signaling, caloric intake, and metabolic homeostasis.
  • Body Composition Pathways: Investigated for possible roles in adipocyte metabolism and lean-mass preservation in preclinical models.
  • Insulin-Related Signaling: Some studies evaluate MC receptor activity in glucose-handling pathways and insulin sensitivity mechanisms.
  • Behavioral & Neuroendocrine Research: MT-2 is widely used in laboratory environments to study central melanocortin pathways that influence motivation, reward, autonomic activity, and neuroendocrine responses.

$66.00

Per Unit
In stock

Free Shipping on All Orders $1000+