PEG MGF

PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic, pegylated variant of Mechano Growth Factor (MGF), an IGF-1Ec splice variant. Pegylation—the covalent attachment of polyethylene glycol (PEG)—extends its half-life from ~5–7 minutes to several hours or days, enhancing bioavailability and therapeutic potential.

Muscle Regeneration: Boosts satellite cell activation and accelerates muscle repair (Kandalla et al., 2011)
Delayed Senescence: ncreases satellite cell proliferative capacity (Riddoch-Contreras et al., 2009)
Reduced Muscle Inflammation: Lowers inflammatory cytokines post-injury (Philippou et al., 2018)
Cardiac Protection: Reduces cardiomyocyte apoptosis and improves cardiac function (Riddoch-Contreras et al., 2009)
Neuroprotection: Protects against brain ischemia and improves motor neuron survival in ALS (Dluzniewska et al., 2005; Riddoch-Contreras et al., 2009)
Bone/Cartilage Repair: Accelerates osteoblast proliferation and cartilage regeneration (Xue et al., 2019
Enhanced Tissue Recovery: Reduces fibrosis and promotes faster muscle healing
Neurodegenerative Support: Improves motor neuron survival and functional recovery in ALS models

Kandalla, P.K., et al. (2011). Mechano Growth Factor E peptide (MGF-E) activates human muscle progenitor cells and induces an increase in their fusion potential at different ages. Mechanisms of Ageing and Development, 132(4), 154-162. DOI: 10.1016/j.mad.2011.02.007
Riddoch-Contreras, J., et al. (2009). Mechano-growth factor, an IGF-I splice variant, rescues motoneurons and improves muscle function in SOD1(G93A) mice. Experimental Neurology, 215(2), 281-289. DOI: 10.1016/j.expneurol.2008.10.014
Dluzniewska, J., et al. (2005). A strong neuroprotective effect of the autonomous C-terminal peptide of IGF-1 Ec (MGF) in brain ischemia. FASEB Journal, 19(13), 1896-1898. DOI: 10.1096/fj.05-3786fje
Xue, S., et al. (2019). Mechano growth factor attenuates mechanical overload-induced nucleus pulposus cell apoptosis through inhibiting the p38 MAPK pathway. Frontiers in Cell and Developmental Biology, 7, 71. DOI: 10.3389/fcell.2019.00071
Philippou, A., et al. (2018). Overexpression of Mechano-Growth Factor Modulates Inflammatory Cytokine Expression and Macrophage Resolution in Skeletal Muscle Injury. Frontiers in Physiology, 9, 999. DOI: 10.3389/fphys.2018.00999

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