PT-141

PT-141 is a synthetic peptide derived from melanocortin hormones. It acts as a melanocortin receptor agonist, primarily targeting MC3R and MC4R in the central nervous system. Unlike PDE-5 inhibitors (e.g., Viagra), PT-141 enhances sexual function via neurological pathways rather than directly affecting vascular function. It is administered subcutaneously and is indicated for hypoactive sexual desire disorder (HSDD) and other forms of sexual dysfunction.

  • Sexual Desire: Increases libido and sexual arousal in men and women
  • Erectile Function: Supports enhanced sexual performance via CNS activation
  • Aphrodisiac Effect: Heightens sexual motivation through melanocortin receptor pathways
  • Non-vascular Mechanism: Effective even for individuals with vascular-related sexual dysfunction
  • Anxiety Reduction: May reduce performance anxiety and improve confidence during intimacy
  • Rapid Onset: Effects observed within ~30 minutes after subcutaneous administration
  • Safety Profile: Minimal systemic side effects; does not significantly affect BP or cardiac function
  1. Khera, M., et al. (2016). Bremelanotide (PT-141) for the treatment of hypoactive sexual desire disorder in women. Journal of Sexual Medicine, 13(9), 1367–1374. DOI.
  2. Sharma, S., et al. (2017). Efficacy and safety of bremelanotide in the treatment of female sexual dysfunction. International Journal of Impotence Research, 29(4), 113–119. DOI.
  3. Carter, D., et al. (2020). The role of melanocortin peptides in sexual arousal and function. American Journal of Clinical and Experimental Urology, 47(6), 2269–2277. DOI.

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