This combination formulation includes three mechanistically distinct peptides PT-141 (Bremelanotide), Kisspeptin, and Pinealon used in research investigating central melanocortin signaling, reproductive hormone pathways, and gene-expression–related neuroprotection.
Each component has been studied separately for its unique interaction with neural, endocrine, and cellular pathways. The combination enables researchers to explore potential multi-pathway interactions involving CNS signaling, GnRH activation, and DNA-level regulatory mechanisms.

Component Mechanisms
(Summaries of published research — NOT effects of this product.)
PT-141 (Bremelanotide)

• Acts as an agonist at MC3R/MC4R receptors in the central nervous system.
• Engages neural circuits related to motivation, behavior, and autonomic signaling.
• Functions independently of vascular nitric-oxide pathways.

Pinealon (Glu-Asp-Arg)

• A synthetic tripeptide capable of interacting with DNA to influence gene expression.
• Investigated for antioxidant activity, MAPK/ERK pathway modulation, and neuroprotective signaling.
• Associated with support of circadian rhythm regulation, oxidative stress response, and cellular resilience.

Kisspeptin

• Activates KISS1R receptors on hypothalamic GnRH neurons.
• Regulates pulsatile GnRH release, which influences downstream LH and FSH secretion.
• Studied for its role in reproductive axis signaling and neuroendocrine regulation.

Mechanistic Rationale for Combination Research
(Mechanistic synergy only — no physiological/clinical claims.)
Research interest in combining these peptides stems from exploring:

• Central CNS activation (PT-141 + Kisspeptin) interacting with
• Gene-level expression modulation (Pinealon)

This multi-pathway approach may allow researchers to investigate:

• Concurrent CNS melanocortin and GnRH pathway activation
• Interactions between neuroendocrine signaling and cellular stress-response pathways
• Coordinated regulation of circadian, behavioral, hormonal, and oxidative-stress networks