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Sermorelin
Sermorelin

Sermorelin

Sermorelin is a peptide that mimics the activity of the natural growth hormone–releasing hormone (GHRH). It binds to GHRH receptors in the pituitary gland, stimulating endogenous production and pulsatile release of growth hormone (GH).

Unlike exogenous GH, Sermorelin supports natural feedback loops, allowing GH and IGF-1 levels to rise within physiologic boundaries. Its short half-life enables rapid clearance, which aligns with the body’s natural nocturnal GH rhythm when administered in the evening.

Sermorelin was historically FDA-approved for pediatric GH deficiency and is widely discussed in research as a physiologically aligned method of stimulating endogenous GH output.

Clinical References

  1. Walker, R.F. (2006). Sermorelin: A Better Approach to Management of Adult-Onset Growth Hormone Insufficiency. Med Hypotheses, 66(5), 925–934.
  2. Prakash, A., & Goa, K.L. (1999). Sermorelin: A Review of Its Use in the Diagnosis and Treatment of Children with Idiopathic Growth Hormone Deficiency. BioDrugs, 12(6), 403–422.
  3. DrugBank. Sermorelin: Uses, Interactions, Mechanism of Action. Accessed 2025.
  4. Silglkas, J.T., et al. (2017). The Safety and Efficacy of Growth Hormone Secretagogues. Sexual Medicine Reviews, 5(2), 170–176.
  5. Ishida, J., et al. (2020). Growth Hormone Secretagogues: History, Mechanism of Action, and Clinical Development. Reviews in Endocrine and Metabolic Disorders, 21, 253–271.

*Supported by human and lab studies—does not imply approved therapeutic use.

  • Natural GH Boost: May increase endogenous GH and IGF-1 while maintaining hypothalamic–pituitary feedback. (Human Study)
  • Supports Pituitary Health: Helps preserve normal pituitary responsiveness to GHRH long-term. (Lab Study)
  • Body Composition Improvements: Research suggests potential increases in lean mass and support for fat reduction aligned with GH signaling. (Human Study)
  • Better Sleep and Vitality: Enhanced nocturnal GH pulsatility may support overall sleep quality and perceived well-being. (Human Study)
  • Diagnostic Tool: Used clinically to evaluate pituitary capacity to release GH. (Human Study)
  • Potentially Lower Risk: May carry a lower theoretical risk of supraphysiologic GH levels compared to direct GH administration because it relies on natural regulatory limits. (Human Study)
  • Flexible Dosing: Short half-life allows timing strategies that align with circadian GH pulses. (Lab Study)

$75.00

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