Sermorelin

Sermorelin is a peptide that works by mimicking the natural growth hormone-releasing hormone (GHRH) produced in the body. It directly stimulates the pituitary gland to increase its own production and release of growth hormone (GH) in a natural, pulsatile way.

Unlike administering synthetic GH, sermorelin supports the body's natural rhythms and feedback systems, leading to a more physiological increase in GH and IGF-1. It has a short half-life, meaning it acts quickly and is cleared from the body relatively fast, making bedtime dosing ideal to enhance the body's natural nocturnal GH pulses. Sermorelin was historically FDA-approved for pediatric GH deficiency and is currently discussed in literature as a potentially more physiological alternative to recombinant GH for adult growth hormone support.

  • Natural GH Boost: Increases your body's own growth hormone and IGF-1 levels while maintaining natural feedback control. (Human Study)
  • Supports Pituitary Health: Helps maintain the pituitary gland's ability to produce growth hormone long-term. (Lab Study)
  • Body Composition Improvements: May help increase lean body mass and reduce fat, consistent with growth hormone's effects. (Human Study)
  • Better Sleep and Vitality: Enhancing natural nighttime GH pulses may lead to improved sleep and overall well-being. (Human Study)
  • Diagnostic Tool: Can be used to assess the pituitary gland's capacity to release growth hormone. (Human Study)
  • Potentially Lower Risk: May carry a lower theoretical risk of abnormal cell growth compared to direct GH injections because it works within the body's natural feedback limits. (Human Study)
  • Flexible Dosing: Its short action allows for precise timing of doses to align with natural hormone rhythms and individual needs. (Lab Study)
  1. Walker, R.F. (2006). Sermorelin: A Better Approach to Management of Adult-Onset Growth Hormone Insufficiency. Medical Hypotheses, 66(5), 925-934.
  2. Prakash, A., & Goa, K.L. (1999). Sermorelin: A Review of its Use in the Diagnosis and Treatment of Children with Idiopathic Growth Hormone Deficiency. BioDrugs, 12(6), 403-422.
  3. DrugBank. Sermorelin: Uses, Interactions, Mechanism of Action. Accessed 2025.
  4. Sigalos, J.T., et al. (2017). The Safety and Efficacy of Growth Hormone Secretagogues. Sexual Medicine Reviews, 5(2), 170-176.
  5. Ishida, J., et al. (2020). Growth Hormone Secretagogues: History, Mechanism of Action, and Clinical Development. Reviews in Endocrine and Metabolic Disorders, 21, 253-271.

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