Sermorelin
Sermorelin is a peptide that works by mimicking the natural growth hormone-releasing hormone (GHRH) produced in the body. It directly stimulates the pituitary gland to increase its own production and release of growth hormone (GH) in a natural, pulsatile way.
Unlike administering synthetic GH, sermorelin supports the body's natural rhythms and feedback systems, leading to a more physiological increase in GH and IGF-1. It has a short half-life, meaning it acts quickly and is cleared from the body relatively fast, making bedtime dosing ideal to enhance the body's natural nocturnal GH pulses. Sermorelin was historically FDA-approved for pediatric GH deficiency and is currently discussed in literature as a potentially more physiological alternative to recombinant GH for adult growth hormone support.