SS-31

SS-31 (elamipretide, also known as Bendavia) is a synthetic, mitochondria-targeted tetrapeptide designed to restore cellular bioenergetics and protect against oxidative stress. It selectively accumulates in the inner mitochondrial membrane by binding cardiolipin, a phospholipid critical for the stability of the electron transport chain.

By stabilizing cardiolipin and mitochondrial complexes, SS-31 prevents cytochrome c destabilization, reduces reactive oxygen species (ROS) production, and preserves mitochondrial membrane potential, thereby optimizing ATP production and cellular energy efficiency.

Mitochondrial Function: Enhanced ATP production and energy output in stressed tissues
Oxidative Stress: Reduced ROS generation and lipid peroxidation
Cell Survival: Stabilized mitochondria, decreased apoptosis under stress
Organ Function: Maintained cardiac, renal, and skeletal muscle performance
Degenerative Processes: Slowed progression of cardiomyopathy, neurodegeneration, and muscle atrophy
Recovery from Injury: Improved recovery in ischemia-reperfusion, acute kidney injury, and metabolic stress
Exercise Tolerance: Improved muscle function, reduced fatigue in mitochondrial dysfunction

Szeto, H.H. (2014). First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics. British Journal of Pharmacology, 171(8), 2029–2050. DOI: 10.1111/bph.12461
Birk, A.V., et al. (2013). The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin. J Am Soc Nephrol, 24(8), 1250–1261. DOI: 10.1681/ASN.2012121216
Chiao, Y.A., et al. (2020). Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice. eLife, 9, e55513. DOI: 10.7554/eLife.55513
Thompson, W.R., et al. (2021). Phase 2/3 trial of elamipretide in Barth syndrome. Genetics in Medicine, 23(3), 471–478. DOI: 10.1038/s41436-020-01006-8
Szeto, H.H., Liu, S. (2018). Cardiolipin-targeted peptides rejuvenate mitochondrial function and promote tissue regeneration during aging. Archives of Biochemistry and Biophysics, 660, 137–148. DOI: 10.1016/j.abb.2018.10.013

$75.00

Per Unit

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