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TB-500
TB-500

TB-500

TB-500 is a synthetic research peptide based on a key amino-acid sequence from thymosin beta-4 (Tβ4), a protein naturally found in mammalian tissues and widely studied in cellular and molecular biology research.

TB-500 is investigated for its interaction with actin-binding pathways, cytoskeletal organization, and cellular migration processes in preclinical systems.

Research explores how TB-500 may influence cellular dynamics such as actin polymerization, tissue remodeling markers, and intracellular signaling networks.

Findings to date are limited to laboratory and animal models, and no effects have been established in humans.

Clinical References

  1. Malinda, K.M., et al. (2012). Thymosin β4: a multi-functional regenerative peptide. Annals of the New York Academy of Sciences, 1269, 1–20.
  2. Philp, D., et al. (2003). Actin-binding role of thymosin β4 promotes angiogenesis. FASEB Journal, 17(14), 2073–2075.
  3. Sosne, G., et al. (2010). Wound-related and anti-inflammatory effects of thymosin β4. Experimental Eye Research, 90(5), 697–703.
  4. Morris, D.C., et al. (2012). Neuroprotective and regenerative activity in preclinical models. Annals of the New York Academy of Sciences, 1270, 89–94.
  5. Hinkel, R., et al. (2021). Developmental peptide research involving thymosin β4 derivatives. Circulation: Cardiovascular Medicine, 8, 681524.

*This compound is provided strictly for laboratory research purposes. It is not approved for human use, clinical use, or therapeutic applications.

  • Cytoskeletal Dynamics: Preclinical work suggests TB-500 may interact with actin-related pathways involved in cellular structure and motility.
  • Cell Migration Markers: Some studies report altered expression of molecules associated with cellular movement and tissue remodeling.
  • Angiogenesis-Related Signals: Laboratory models show changes in markers linked to endothelial cell behavior and new-vessel formation pathways.
  • Inflammation-Associated Markers: Preclinical systems have noted modulation of cytokine-related signaling during cellular stress conditions.
  • Musculoskeletal Research Models: Animal studies have examined TB-500 in the context of tendon, muscle, and connective-tissue cellular environments.
  • Ocular and Neurological Models: Certain non-clinical models explore TB-500’s potential influence on corneal and neural tissue signaling pathways.
  • Cellular Stress Response: Some research indicates interactions with pathways related to oxidative stress, cellular protection, and regeneration-associated markers.

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