Thymalin

Thymalin is a polypeptide bioregulator derived from calf thymus, composed of a mixture of short bioactive peptides; primarily EW (Glu-Trp, Thymogen), KE (Lys-Glu), and EDP (Glu-Asp-Pro)

These peptides operate via epigenetic and gene regulatory mechanisms, directly binding DNA and histone proteins to modulate transcription of genes involved in immune function, cellular differentiation, stress response, and aging. Unlike traditional immune modulators, Thymalin penetrates cellular and nuclear membranes to influence T-cell maturation, cytokine production, hemostasis, and stress protein synthesis.

T-cell Function: Increases CD4+ and CD8+ counts; improves immune surveillance
COVID-19 Support: 50% reduction in hospital mortality in severe cases
Lymphocyte Recovery: 92% increase in blood lymphocyte counts; faster immune normalization
Anti-inflammatory: 6.5-fold decrease in IL-6; 3.3-fold reduction in CRP
Hemostasis: 30% reduction in fibrinogen; normalized D-dimer levels
Infection Resistance: 2–2.4x reduction in respiratory infections in elderly populations
Post-surgical/chemotherapy Recovery: Accelerated immune function restoration
Geroprotection: Improved survival rates; slows age-related immune decline
Hematopoiesis: Enhanced RBC, WBC, and platelet production
Safety Profile: Well-tolerated in elderly populations with minimal side effects

Khavinson, V.Kh., et al. (2021). The use of Thymalin for immunocorrection and molecular aspects of biological activity. Biology Bulletin Reviews, 11(4), 377–382. DOI: 10.1134/S2079086421040046
Kuznik, B.I., et al. (2021). Peptide drug Thymalin regulates immune status in severe COVID-19 older patients. Advances in Gerontology, 11(4), 368–376. DOI: 10.1134/S2079057021040068
Khavinson, V.Kh., et al. (2020). Thymalin: activation of differentiation of human hematopoietic stem cells. Bulletin of Experimental Biology and Medicine, 170(1), 118–122. DOI: 10.1007/s10517-020-05016-z
Anisimov, V.N., et al. (2010). Peptide bioregulation of aging: results and prospects. Biogerontology, 11(2), 139–149. DOI: 10.1007/s10522-009-9249-8
Khavinson, V.Kh., et al. (2013). Peptide bioregulators: a new class of geroprotectors. Advances in Gerontology, 3(3), 225–235. DOI: 10.1134/S2079057013030065

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