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TRZ
TRZ

TRZ

TRZ is a synthetic peptide analog studied for its ability to activate both the glucose-dependent insulinotropic polypeptide (GIP) receptor and the GLP-1 receptor. Known in the scientific literature as a “dual incretin receptor agonist,” it has been widely researched for its role in metabolic signaling pathways, energy balance studies, and endocrine-related mechanisms.

GIP Receptor Pathway (GIPR)
Studies describe GIPR activation as influencing:

  • cAMP/PKA intracellular signaling
  • stimulation of insulin secretion (model systems)
  • β-cell function and anti-apoptotic signaling
  • energy-balance pathways


GLP-1 Receptor Pathway (GLP-1R)
Published research notes involvement in:

  • GLP-1 mediated signaling cascades
  • effects on gastric emptying models
  • hypothalamic appetite-signaling circuits
  • modulation of glucagon-related pathways

Clinical References

  1. Nauck, M.A., et al. (2022). Cardiovascular Diabetology, 21(1), 169. DOI: 10.1186/s12933-022-01604-7
  2. Willard, F.S., et al. (2020). JCI Insight, 5(17), e140532. DOI: 10.1172/jci.insight.140532
  3. Frías, J.P., et al. (2021). NEJM, 385(6), 503-515. DOI: 10.1056/NEJMoa2107519
  4. Jastreboff, A.M., et al. (2022). NEJM, 387(3), 205-216. DOI: 10.1056/NEJMoa2206038
  5. Yang, J., et al. (2024). Frontiers in Pharmacology, 15, 1453825. DOI: 10.3389/fphar.2024.1453825.
  • Dual Incretin Receptor Signaling: TRZ is commonly examined in studies involving simultaneous activation of GIP and GLP-1 receptors and the resulting downstream intracellular signaling pathways.
  • Metabolic Pathway Investigations: Research explores how dual incretin receptor agonists influence cellular cAMP signaling, β-arrestin–associated pathways, and endocrine system responses.
  • Energy Balance & Appetite Signaling: Scientific literature discusses the involvement of GLP-1 and GIP receptor pathways in satiety signaling, gastric motility research, and hypothalamic signaling networks.
  • Glucose Regulation Mechanisms: TRZ is studied in the context of incretin-mediated pathways associated with insulin secretion, glucagon modulation, and pancreatic β-cell signaling.
  • Body Composition & Adipose Biology: Academic research evaluates the influence of dual-incretin agonists on adipocyte signaling, lipid metabolism markers, and nutrient-partitioning pathways.

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